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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: Compounder on June 12, 2019, 11:48:54 PM

Title: L-Serine
Post by: Compounder on June 12, 2019, 11:48:54 PM

Hi
Does anyone know if L-serine is affected by indirect heat at 70c for 10min. I am formulating a lozenge with Serine and to make it requires an anhydrous base melted to 60c to 70c that the serine is added to. My concern is if the serine may be ‘altered’ in some way. All assistance much appreciated.

Title: Re: L-Serine
Post by: phth on June 14, 2019, 01:29:38 AM

U get less L-S and more D/L-S only. Heat will deprotonate the alcohol and the alpha position, but the enolate won't add to another serine.