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Specialty Chemistry Forums => Materials and Nanochemistry forum => Topic started by: watizit97 on July 05, 2019, 11:06:30 PM

Title: Rotaxane - Stopper Synthesis
Post by: watizit97 on July 05, 2019, 11:06:30 PM

Hello.

I am a research student currently exploring on how to synthesize water-soluble rotaxanes via Diels-Alder Reaction. But I have a problem what compound I should use as the stopper of the rotaxane.

My criteria for a stopper are :

1) It must be big/bulky (So the γ-cyclodextrin will not leave the rotaxane even after combining the Diene and the Dienophile via Diels-Alder Reaction)
2) It must have a hydroxyl group (This is because both of my diene and dienophile has a carboxylic acid group at end of it, and I would like to combine them with the stopper via esterification)
3) It must be hydrophilic.

I would greatly appreciate if you could attach any kinds of literature to your statement or other alternatives in creating the stopper.

Thank you.

Title: Re: Rotaxane - Stopper Synthesis
Post by: sjb on July 06, 2019, 04:03:19 PM

Duplicate, locked here