Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: Mater1991 on July 12, 2019, 05:50:29 AM
-
Hello everyone:
I have some graphene oxide(GO) with carboxylic acid functional groups that I wanted to couple to aminated graphene oxide(AGO).In order to activate carboxylic acids of graphene oxide that I put EDC/NHS to the solution.I have the question that how high the temperature of experiment EDC/NHS will fail,I want to get a fast and feasible reaction rate.
So,what's your temperature in EDC/NHS experiment,I wanted to get your opinions first. Any advice appreciated!
Some more info:
Solvent:DMF
Now the experimental temperature is 185℉/85℃
-
I've always done it at room temperature overnight. I feel like the only time I've seen raised temps for it was to better solvate one of the reagents.
How did it go at 85°C?
-
My experience is at room temperature also - and usually in water. Can you use a different coupling agent in DMF?
-
Do it in acetonitrile. The DCU byproduct is poorly soluble in it, so the workup is easier.