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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: Cocainut on August 16, 2019, 11:29:42 AM

Title: Acid Protection Cross coupling reactions
Post by: Cocainut on August 16, 2019, 11:29:42 AM

Whenever I search in litterature for a coupling reaction I often find that the carboxylic acid is being protected and I am curious if there are any particular reasoning behind this?
I've tried searching the litterature but I am having trouble finding any useful answers.

Title: Re: Acid Protection Cross coupling reactions
Post by: OrganicDan96 on August 16, 2019, 12:00:51 PM

migth be that carboxylic acids are very hard to handle. they stick to silica so not easy to column and can be a bit water soluble making isolation hard. what is the reaction you are investigating?