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Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: jeffmoonchop on November 26, 2019, 05:22:43 PM

Title: Sucrose Toxicity
Post by: jeffmoonchop on November 26, 2019, 05:22:43 PM

Hi all, when considering a sucrose solution for IV injection, I have heard that it can be toxic. I want to know how toxic it is.

I searched online for toxicity values and mostly get oral toxicity (LC50 of 29.7g/kg in rat). I'm assuming this value is much lower for IV injection due to the lack of digestion prior to entering the bloodstream.

I found a couple statements which say that renal failure is possible, but am finding it hard to find anything regarding IV dose toxicity of sucrose.

Has anyone else heard that sucrose is toxic by IV injection? I would love to find some references or studies which prove this, as well as actual toxicity values.

thanks,

Title: Re: Sucrose Toxicity
Post by: AWK on November 26, 2019, 06:16:33 PM

Iron sucrose injection - Venofer.

Title: Re: Sucrose Toxicity
Post by: jeffmoonchop on November 26, 2019, 07:25:54 PM

thanks, I just looked into it, looks like the maximum surcose dose for that is 50mg/kg assuming 62kg human and they report no sucrose related side effects. Thats good to know. I'm hoping to get any examples of extreme sucrose injection up to 1g/kg. I'll keep looking but thanks for any suggestions in the meantime.