Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: xshadow on February 18, 2020, 03:35:24 PM
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Hi
I have some doubt about the "type"" of KIE that I have when I label the green carbon :
(https://i.imgur.com/DvyZ7La.jpg)
Is the breaking of a C=C (only the π-bond part) considered a primary isotope effect or a secondary isotope effect ?!?
(breaking the double bond the carbon changes its hybridation sp2-->sp3)
Thanks!!
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I think it is primary - you are breaking a bond to the isotopically substituted atom.
But 12C vs 13C gives a small effect even for primary.
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The first step is a bond-making step. I would also refer to the associated kinetic isotope effect as a primary isotope effect.
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Ook...thanks
So also the breaking of a π C=C is a primary isotope effect
Because usually I've seen σ C-H broken for 1° KIE and I didn't know of an example like this...
Thanks
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Maybe I am confused. Which carbon is labeled with C-13? There are some inverse secondary isotope effects involving C-D bonds; therefore, there might be an analogous phenomenon for carbon depending on the position of the label.
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Maybe I am confused. Which carbon is labeled with C-13? There are some inverse secondary isotope effects involving C-D bonds; therefore, there might be an analogous phenomenon for carbon depending on the position of the label.
Hi
Labelled only the green carbon of the figure...the one witch -Br and -OCH3 bonded
No other atom labelled (hydrogen pther carbon)
That green carbon:
-Changes hybridization (usually this gives a secondary effecy)
-one of its bonds is broken (primary effect)
So a primary effect + a secondary one?(but i see only the primary )
Thanks
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We are moving beyond my knowledge of kinetic isotope effects. I think that the labeled carbon will see effects both from the bonds made or broken and the change in hybridization, and I imagine that the primary effect is larger. However, I am not absolutely sure how this will play out. If the carbon with the negative charge were labeled instead, I think that you would only see the secondary isotope effect.