Chemical Forums

Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: JoeyBob on February 28, 2020, 08:53:56 PM

Title: Is this mechanism correct and if it is would it give a good yield?
Post by: JoeyBob on February 28, 2020, 08:53:56 PM

See below. The product is the racemic compound.

Title: Re: Is this mechanism correct and if it is would it give a good yield?
Post by: hollytara on February 28, 2020, 10:33:42 PM

It isn't a mechanism, it is a proposed synthesis or synthetic scheme. 

Title: Re: Is this mechanism correct and if it is would it give a good yield?
Post by: hollytara on February 28, 2020, 10:38:45 PM

Most of the steps are good - but the last two aren't the best.  The imine from the acetophenone and methanamine can be reduced in situ using sodium cyanoborohydride.  Isolating the imine is not always that easy - it can easily hydrolyze. 

Title: Re: Is this mechanism correct and if it is would it give a good yield?
Post by: JoeyBob on February 29, 2020, 12:33:59 AM

Quote from: hollytara on February 28, 2020, 10:38:45 PM

Most of the steps are good - but the last two aren't the best.  The imine from the acetophenone and methanamine can be reduced in situ using sodium cyanoborohydride.  Isolating the imine is not always that easy - it can easily hydrolyze.

Thanks. Toluene is kinda expensive. Is phenylacetone easy to get?

Title: Re: Is this mechanism correct and if it is would it give a good yield?
Post by: rolnor on February 29, 2020, 04:38:15 AM

Synthesis of amphetamine or other drugs have no place here.

Title: Re: Is this mechanism correct and if it is would it give a good yield?
Post by: Borek on February 29, 2020, 07:14:04 AM

Please read the forum rules (https://www.chemicalforums.com/index.php?topic=65859.0). We have no problems discussing mechanisms, but not synthesis schemes.

Topic locked.