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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: Allendo on May 08, 2020, 01:23:54 AM

Title: Ruff degradation
Post by: Allendo on May 08, 2020, 01:23:54 AM

Hi Team,
About ruff degradation, step 2: Using reagent H2O2 and Fe2(SO4)3 to achieve the loss of CO2 and oxidation to aldehyde. My question is that why would not the btm primary alcohol also oxidized into an aldehyde?

Thanks
Allen

Title: Re: Ruff degradation
Post by: rolnor on May 08, 2020, 06:14:40 AM

Is the loss of CO2 the same mecanism as oxidation of alcohol to aldehyde?

Title: Re: Ruff degradation
Post by: AWK on May 08, 2020, 06:21:32 AM

This is oxidative decarboxylation, not alcohol oxidation. Look in the literature for the original proposition of the Ruff degradation mechanism - there are many.