Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: samra on August 10, 2020, 04:07:28 PM
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You are given a mixture of quercetin and gingerol that need to be separated. Unfortunately, these two compounds have very similar boiling points, molecular weights, and polarities. Describe a method that should provide a baseline separation of these two compounds and explain why it should work. Give details of the type of column, detector, and any other major equipment or procedures necessary to complete your separation. Using your proposed method, which compound should elute first and why?
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The question contains the demanded answer, with "column" and "elute".
The melting points are very far from an other, this might have been an alternative.
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I think they are very different in polarity/hydrophobisity, both a straight-phase or reversed-phase column would separate these two without any problem. Quercetine on straight-phase is EtOAc/MeOH 20:1 Gingerol is EtOAc/hexane 1:1 is my suggestion. You can use a gradient with these two mobile-phases.
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You could use a mobile phase that takes advantage of the ligation chemistry of the catechol moiety.
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Or a stationary phase that does.