Chemical Forums

Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: Qwerius_1 on September 28, 2020, 02:53:05 PM

Title: ADP hydrolysis to AMP yields the same E as less stable ATP to ADP, why?
Post by: Qwerius_1 on September 28, 2020, 02:53:05 PM

I was learning some biochem. and I found out that ADP is more stable that ATP because of intramolecular repulsion of negative charges and because of resonance of ADP.  I then thought that because of this, hydrolysis of ADP to AMP has to yield less energy that that of ATP, but  found out that the ∆G is the same. How is this possible??

Title: Re: ADP hydrolysis to AMP yields the same E as less stable ATP to ADP, why?
Post by: Babcock_Hall on September 29, 2020, 10:58:54 AM

Are you familiar with the terminology of phosphoanhydride bond?  Are you familiar with the term high-energy bond?

Title: Re: ADP hydrolysis to AMP yields the same E as less stable ATP to ADP, why?
Post by: Babcock_Hall on September 30, 2020, 08:02:57 AM

A high-energy bond is a bond for which the hydrolysis reaction has ΔG°' less than -25 kJ/mol.  Are same factors which make the β,γ bond in ATP a high energy bond also a factor in the α,β bond in ADP?