Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: idis on December 03, 2020, 01:00:36 PM
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Hey guys, I have the task of comparing the synthesis of benzimidazole and benzothiazole from 1,2-phenylenediamine and 2-aminothiophenol. So far i have found that in general, benzimidazole formation takes relatively longer time for completion as compared to the time required for benzothiazoles due to the reduced nucleophilicity of –NH moiety as compared to sulphur atom. Also benzimidazole synthesis does require a stronger oxidant and harsh reaction conditions. Does anyone have any other ideas and examples? Thank you