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Chemistry Forums for Students => Physical Chemistry Forum => Topic started by: VeteranSkiver_29 on February 08, 2021, 06:48:47 AM

Title: Factors affecting the solubility (lipophilicty) of drugs
Post by: VeteranSkiver_29 on February 08, 2021, 06:48:47 AM

Hi,

I am currently completing a chemistry database investigation and would appreciate input into the variables I could measure. I am looking to use lipophilicity (logP) as a measurement to quantify the solubility in drugs. Lipophilicity would be my dependent variable and my independent variables would be the polar surface area. Preferably, I would need another independent variable and I am struggling to see what else could affect lipophilicity. Could I use melting points or molecular mass?

Any other suggestions are helpful.

Btw, I have graphed my polar surface area and lipophilicity data and it shows a negative linear relationship.

Title: Re: Factors affecting the solubility (lipophilicty) of drugs
Post by: hypervalent_iodine on February 09, 2021, 06:39:59 PM

This might be a useful resource for you: https://onlinelibrary.wiley.com/doi/full/10.1002/jps.10178