Chemical Forums

Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: whitecoatblackhat on April 22, 2021, 08:20:35 PM

Title: Ketoconazole Solubility
Post by: whitecoatblackhat on April 22, 2021, 08:20:35 PM

Hello,

I'm trying to create a non-irritating, "gentle" alternative to the famous Nizoral shampoo.

And I simply can't find any skin-friendly, non-toxic solvents that solubilise ketoconazole (KTZ) at concentrations of 2% (or 1%).

I'm purposefully avoiding the sulfates used in Nizoral, even though they're capable of dissolving KTZ.

The only other Ketoconazole shampoo that doesn't use sulfates is Regenpure DR and they are barely able to get the ketoconazole concentration up to 1%.

The things that I've had slight success with are:

- Polysorbate 80
- Reducing the pH
- Ethanol (not suitable for a shampoo formulation)
- Propylene glycol (not suitable for a shampoo formulation)

Any thoughts, ideas, suggestions? All will be greatly appreciated!

Thank you

Title: Re: Ketoconazole Solubility
Post by: rolnor on April 23, 2021, 02:35:34 AM

Ketocole containes a imizdazole ring that is a weak base so low pH is good. How about diluted lactic acid?

Title: Re: Ketoconazole Solubility
Post by: Borek on April 23, 2021, 03:19:05 AM

To all: technically the thread goes against the forum rules, I am trying to establish a way to help OP as from my understanding they are not some random Joe Average trying to make their own meds/cosmetics to save few bucks.

Also not that the discussion of the theory behind processes and possible methods to use to solve a problem fit the rules.