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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: natalie5933 on June 13, 2022, 10:49:31 PM

Title: chromatography
Post by: natalie5933 on June 13, 2022, 10:49:31 PM

If I want to separate 2 things. Their Rf in the current solvent system is 0.7 and 0.8 i.e. extremely high, not good for separation. Then to lower their Rf should I use a more polar or less polar mobile phase than the one I am using now?? please explain!

Title: Re: chromatography
Post by: rolnor on June 14, 2022, 12:18:14 AM

Less polar if it is straight-phase silica gel. What system do you use currently? Can you give the structure if your compounds?

https://en.wikipedia.org/wiki/Chromatography

Title: Re: chromatography
Post by: Babcock_Hall on June 14, 2022, 09:48:37 AM

@OP, Can you provide a simple model that rationalizes this phenomenon?