Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: Raven on July 14, 2022, 05:04:30 PM
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Hello,
I need to free-base a large quantities ( 1-2 kg) of an amine hydrochloride zinksalt. Can someone recommend a method.
The usual basification and extraction with DMC, is not suitable, due to the that some of the zinc is extracted into the DMC.
Thanks
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Try ether
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Thanks rolnor
Ether is no go in large quantities, due to explosion risk and peroxide formation.
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Toluene? What scale is it and whats the structure of the free base?
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Scale: 1-2 kg
http://www.chemspider.com/Chemical-Structure.56136.html?rid=ba6106c9-b743-4b4c-aade-bb0ddc91e868&page_num=0 (http://www.chemspider.com/Chemical-Structure.56136.html?rid=ba6106c9-b743-4b4c-aade-bb0ddc91e868&page_num=0)
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That must be highly crystaline? Can you not crash it out and collect on a filter?
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You can dissolve zinc and chloride with warm sodium hydroxide, then the base will crash out.
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How do I prevent the formed Zn(OH)2 to crash out?
Zn2+ +2OH- :rarrow: Zn(OH)2 :spindown:
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It will form sodium zincate.
https://en.wikipedia.org/wiki/Sodium_zincate