Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: CHEV on January 24, 2007, 03:52:53 PM
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it's me again... my teacher asked me a question and I've been looking all over the internet trying to fin the answer but i can't find it. i need to know why despite it's toxicity, benzene and aromatic compounds haven't been replaced yet, i mean, why using something that's toxic and cancerogenic instead of something that's harmless?? please someone help meeeee
thanks
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aromatic by itself isn't toxic. three of the proteineogenic amino acids have aromatic groups. many pharmaceuticals have aromatic groups
in chemical reactions benzene is often replaced by toluene because it is less toxic. but you sometimes need an aromatic solvent, it often works better if you have aromatic substances reacting
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it's me again... my teacher asked me a question and I've been looking all over the internet trying to fin the answer but i can't find it. i need to know why despite it's toxicity, benzene and aromatic compounds haven't been replaced yet, i mean, why using something that's toxic and cancerogenic instead of something that's harmless?? please someone help meeeee
thanks
Every chemical is toxic, it's the dose/exposure that matters. Adrien Albert wrote a famous book in 1953 called "Selective Toxicity" on the issue. It's possible to do a reaction in 20,000 L of benzene and with careful control conditions (such that none escapes) be perfectly safe. Chemists work with toxic and carcinogenic chemicals all the time. Working safely is the key.
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it is not replaced becoz it satisfy the chemist needs to synthesize a wide variety of drugs
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firstly because it is very cheap, secondly because it has a low bp, third because its a very good azeotrope for water removal, combine with second affirmation, it means that you dont have to boil very high temps (like with toluene) preserving your precious compounds from decomposition, fourth, it has only one peak in 1H nmr and 13C nmr, finally six, even if it is toxic, a good chemist should NEVER die of cancer, it is prohibited.
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firstly because it is very cheap, secondly because it has a low bp, third because its a very good azeotrope for water removal, combine with second affirmation, it means that you dont have to boil very high temps (like with toluene) preserving your precious compounds from decomposition, fourth, it has only one peak in 1H nmr and 13C nmr, finally six, even if it is toxic, a good chemist should NEVER die of cancer, it is prohibited.
I don't see how having only one signal means anything.
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how would u use d6 benzene... or u think it is non toxic?
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I don't see how having only one signal means anything.
It means a lot if you have a complicated spectrum! Also, using different solvents that have different residual frequencies in the NMR can help to see peaks that are covered by solvent resonances.
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I don't see how having only one signal means anything.
It means a lot if you have a complicated spectrum! Also, using different solvents that have different residual frequencies in the NMR can help to see peaks that are covered by solvent resonances.
I figured that had something to do with it. I'm so used to seeing 4 peaks. ;D