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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: islandscience on June 05, 2007, 01:29:16 PM

Title: Guanidines from cyanamides
Post by: islandscience on June 05, 2007, 01:29:16 PM

Been trying to follow a prep which involves refluxing an amine  salt and my cyanamide in chlorobenzene but still no luck. Any suggestions?

Title: Re: Guanidines from cyanamides
Post by: Custos on June 05, 2007, 10:27:50 PM

Hindered amines make this reaction difficult - a Lewis acid like AlCl₃ often helps. Check out Organic Synthesis (http://www.orgsyn.org/) Collective Vol 4, page 769.