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Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: sxdxland on June 19, 2007, 12:43:21 AM

Title: (Z-Cys-OMe)2
Post by: sxdxland on June 19, 2007, 12:43:21 AM

hello,all
I want to synthesis the (Z-Cys-OMe)2,CAS:3693-95-6


but i do not know how to do it ,
and i can not find some data for it (for example the mp.[a]20/D )
can you help me ?
3Q to you!

Title: Re: (Z-Cys-OMe)2
Post by: sxdxland on June 19, 2007, 01:52:35 AM

nobody can help me ?

Title: Re: (Z-Cys-OMe)2
Post by: sjb on June 20, 2007, 07:54:15 AM

Assuming the Z = benzyloxycarbonyl, I'd imagine the cysteine would dimerise relatively easily, even in air, so

Cys -> CysOMe (with TMS diazomethane or similar? - may hit the SH too?) -> Z-CysOMe -> (Z-CyS-OMe)2?

Title: Re: (Z-Cys-OMe)2
Post by: sxdxland on June 20, 2007, 09:19:19 PM

thank sjb
now my synthesis route is (Cys)₂ --->(CBZ-Cys-OH)₂
--->(CBZ-Cys-OMe)₂
(CBZ-Cys-OH)₂ and (CBZ-Cys-OMe)₂ i have got,but I not sure ,because I   have less information about them, maybe somebody can help me.