Chemical Forums

Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: redfox on November 22, 2007, 12:57:08 PM

Title: Metabolism of Metronidazole...inhibition by CO
Post by: redfox on November 22, 2007, 12:57:08 PM

I'm trying to write a report on something I don't really understand very well, despite having read up on related subjects and reagents involved.

Anaerobic bacteria were bubbled with CO and treated with Metronidazole. I have said that bacteria weren't killed as the environment was anaerobic, but cyt p450 was inhibited by the CO and so was unable to metabolise Metronidazole. However, the Metronidazole was metabolised and I have to find out why. I've suggested that epithelial cells present may have played a part but I'm not sure how exactly!

Can anyone offer a suggestion please?

Thanks:)

Title: Re: Metabolism of Metronidazole...inhibition by CO
Post by: AhmedEzatAlzawalaty on December 06, 2007, 01:56:07 PM

when nitro becomes reduced it gives unstable intermediate thats what i think and this unstable intermediate may be removed