Chemical Forums

Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: Cocain on December 03, 2007, 06:02:47 AM

Title: organic chemistry of Drugs synthesis?
Post by: Cocain on December 03, 2007, 06:02:47 AM

Can someone help me please? I don't know the way to synthesize promethazine (an antihistamine drugs) and where to find some information about this drugs!

Title: Re: organic chemistry of Drugs synthesis?
Post by: russellm72 on December 03, 2007, 07:30:48 AM

Hi,

For what reason do you want to synthesise this drug? If you are a student or work for industry you wouldn;t be asking this question..

More info and we might help you.

R.

Title: Re: organic chemistry of Drugs synthesis?
Post by: AWK on December 03, 2007, 07:45:12 AM

Prometazine is a relatively simple derivative of phenothiazine.
Just find a textbook on drug synthesis in library, eg
The Organic Chemistry of Drug Synthesis. by Daniel Lednicer.

Title: Re: organic chemistry of Drugs synthesis?
Post by: agrobert on December 03, 2007, 02:14:52 PM

are you making purple drank?

Title: Re: organic chemistry of Drugs synthesis?
Post by: Cocain on December 04, 2007, 08:10:13 AM

I read the book "The Organic Chemistry of Drug Synthesis. by Daniel Lednicer." but it provides me only some general information about Promethazine. My professor asks me to know at least 3 ways to synthesis P., i've just know only one. I've found on Internet for a long time but no more useful information. Do you know some useful internet links? Thanks!

Title: Re: organic chemistry of Drugs synthesis?
Post by: AWK on December 04, 2007, 08:40:59 AM

Phenothiazine can be obtained in very different reactions. In some of them you can add side chain before cyclization.
Try this way.

The side chain is branched. you can try a different approach to its synthesis

Title: Re: organic chemistry of Drugs synthesis?
Post by: Cocain on December 04, 2007, 10:28:23 AM

Yeah, thank mod very much! I'll try that way. But I think my methods are only used in lab. However. my professor wants the processes in details which are applied in industrial chemistry. I think it's very difficult for a student like me!!! I tried to look up in some patent websites but there is only promethazine HCl. Can someone help me please?

Title: Re: organic chemistry of Drugs synthesis?
Post by: AWK on December 04, 2007, 10:59:12 AM

Industrial processes were patented. Prometazine.HCl is a real drug used. Prometazine itself is a base, hence this is only neutralization reaction: amine + HCl. Dont worry about this.

Title: Re: organic chemistry of Drugs synthesis?
Post by: Cocain on December 05, 2007, 04:59:35 AM

Oooh! I'm so silly. Thank mod!