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Chemistry Forums for Students => Inorganic Chemistry Forum => Topic started by: profmsg on February 19, 2008, 07:03:19 AM

Title: protecting group
Post by: profmsg on February 19, 2008, 07:03:19 AM

im using protecting group, AC2O for protecting of carboxylic groups in 2,6 dichloropyridine-4-carboxylic acid. i dont know the reaction condiditons and  how much AC2O will need for 100mg of 2,6dichloropyridine 4 carboxylic acid..

and full reaction mechanims as well

if anybody have idea plz reply me
thanks
profmsg

Title: Re: protecting group
Post by: AWK on February 19, 2008, 09:24:21 AM

Mixed anhydride is rather an activating group

Title: Re: protecting group
Post by: profmsg on February 20, 2008, 09:04:26 AM

Quote from: AWK on February 19, 2008, 09:24:21 AM

Mixed anhydride is rather an activating group

is that means -COOH will not be protected but activated and i will loose cooh group.

Title: Re: protecting group
Post by: AWK on February 20, 2008, 10:09:46 AM

Mixed anhydrides are used in synthesis of many compounds, eg esters or  peptides.

http://content.arkat-usa.org/ARKIVOC/JOURNAL_CONTENT/manuscripts/2005/EJ-1500CP%20as%20published%20mainmanuscript.pdf