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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: profmsg on July 30, 2008, 09:40:03 AM

Title: amine and carboxylic coupling reacation
Post by: profmsg on July 30, 2008, 09:40:03 AM

hi,
im trying to get coupling reaction between compound containing -NH2 and compound containing -COOH group. i used mes bufer and edc in ice bath. i extracted product in acetonitrile wash. however, the product is in oil form. but i want the product in powder or crystal forms. anybody have any idea, how to convert product in powder.
thanks

Title: Re: amine and carboxylic coupling reacation
Post by: azmanam on July 30, 2008, 09:48:12 AM

Probably not going to happen.  Is it a known compound that is known to be a solid?  You can't just will things to crystallize.  What's the rest of the structure look like?

Title: Re: amine and carboxylic coupling reacation
Post by: profmsg on July 30, 2008, 09:52:11 AM

Quote from: azmanam on July 30, 2008, 09:48:12 AM

Probably not going to happen.  Is it a known compound that is known to be a solid?  You can't just will things to crystallize.  What's the rest of the structure look like?

actually, the compound is long chain molecule with similar like this -sH IN ONE SIDE AND BISPHOSPHONATE ON OTHER SIDE...
THE COMPOUND IS SIMILAR TO THE COMPOUND AS IN BELOW JOURNAL
THNKS

Journal of Chromatography A, 914 (2001) 105–110
www.elsevier.com/ locate /chroma
Ion-exchange liquid chromatographic analysis of bisphosphonates
by on-line post-column photochemical reaction and
spectrophotometric detection
Sean X. Peng*, Susan M. Dansereau
The Procter & Gamble Company, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040-9462, USA

Title: Re: amine and carboxylic coupling reacation
Post by: macman104 on July 30, 2008, 10:46:09 AM

This comopund?  I thought you said it was a long chain molecule?  Is there a way you can post your molecule?