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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: vivioo7 on January 03, 2010, 12:02:14 PM

Title: Using EDAC in a carboxylic acid with amine reaction to form an amide?
Post by: vivioo7 on January 03, 2010, 12:02:14 PM

Has anyone done this?  I'd trying to figure out the reaction conditions.  Thanks for any help

Title: Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?
Post by: lmlh on January 04, 2010, 07:01:08 AM

it is ok in dry dichloromethane at RT

Title: Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?
Post by: Zainb on January 04, 2010, 09:03:14 AM

Check this link:
http://en.wikipedia.org/wiki/Carbodiimide

Title: Re: Using EDAC in a carboxylic acid with amine reaction to form an amide?
Post by: xiaoruan on January 05, 2010, 11:20:16 AM

dissolve the acid(dry CH2Cl2 or dmf as solvent), add in the  EDAC in ice-bath and then add in amine ,half an hour later remove the ice-bath ,stir in RT for overnight,remove the solvent under reduced pressure ,dissolve the residue with EtOAc and freeze for half an hour in refrigeratory ,filter out the EDAC, remove the EtOAc the residue was isolated
by column chromatographyon a silica gel column