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Chemistry Forums for Students => Physical Chemistry Forum => Topic started by: h1234 on May 21, 2010, 11:28:38 AM

Title: patation coefficient
Post by: h1234 on May 21, 2010, 11:28:38 AM

Hi

Can anyone tell me how (weak benzoic acid) ionisable group on a drug molecule influence its its partition coefficient?

I think what happens that ionisable group increase water solubility and decrease lipid solubility which decrease the partition coefficient value.

Kind regards

Title: Re: patation coefficient
Post by: zizics on May 25, 2010, 07:15:21 AM

Hi, I don't have a massive experience with partition coefficients but from my understanding adding in hydrophilic groups will increase it as its water solubility will obviously increase. In the future, you could try using an online logP (log Partition Coefficient) calculator like at http://www.molinspiration.com/cgi-bin/properties (http://www.molinspiration.com/cgi-bin/properties). Just draw the structure and click calculate properties and look at the miLogP value.

Adam.

Title: Re: patation coefficient
Post by: h1234 on May 25, 2010, 04:46:26 PM

Quote from: zizics on May 25, 2010, 07:15:21 AM

Hi, I don't have a massive experience with partition coefficients but from my understanding adding in hydrophilic groups will increase it as its water solubility will obviously increase. In the future, you could try using an online logP (log Partition Coefficient) calculator like at http://www.molinspiration.com/cgi-bin/properties (http://www.molinspiration.com/cgi-bin/properties). Just draw the structure and click calculate properties and look at the miLogP value.

Adam.

Thanks Adam
i understand what you said ... Exam is gone yesterday thanks alot anyway