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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: shrikantvarma on September 28, 2010, 11:55:47 AM

Title: cyanohydrin from O-silylated cyanohydrin
Post by: shrikantvarma on September 28, 2010, 11:55:47 AM

how to prepare cyanohydrin from O-silylated cyanohydrin ??

Title: Re: cyanohydrin from O-silylated cyanohydrin
Post by: discodermolide on September 28, 2010, 12:42:39 PM

Quote from: shrikantvarma on September 28, 2010, 11:55:47 AM

how to prepare cyanohydrin from O-silylated cyanohydrin ??

Try HF/acetonitrile at 0°C-RT

Title: Re: cyanohydrin from O-silylated cyanohydrin
Post by: shrikantvarma on September 28, 2010, 12:44:24 PM

can we use aq.hydrochloric acid instead of HF

Title: Re: cyanohydrin from O-silylated cyanohydrin
Post by: discodermolide on September 28, 2010, 01:43:09 PM

Quote from: shrikantvarma on September 28, 2010, 12:44:24 PM

can we use aq.hydrochloric acid instead of HF

No HF is more selective. With HCl you may eliminate to get the alpha-beta unsaturated nitrile.