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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: malviyangr on April 22, 2011, 07:51:02 AM

Title: synthesis of N-substituted Imidazole/pyrazole
Post by: malviyangr on April 22, 2011, 07:51:02 AM

Hi to all.
I want to make N-substituted pyrazole/imidazole using alpha,alpha'-para bromo xylene and pyrazole/imidazole. I want to use the NaOH-THF solvent system whether it is appropriate or not? And in the same solvent system, whether I should take dried THF or ordinary one?
or Can we use methanol instead of THF above , will it react with my bromo-compound.(One has used methanol with chloro compound).
Suggest any other solvent if anyone has done this reaction?
Thanks for any help...

Title: Re: synthesis of N-substituted Imidazole/pyrazole
Post by: Dan on April 22, 2011, 07:57:41 AM

For the convenience of others, I have attached the scheme from the .doc below.

You'd probably be better off with a non-nucleophilic base.

Title: Re: synthesis of N-substituted Imidazole/pyrazole
Post by: azmanam on April 22, 2011, 08:29:49 AM

I've never run this reaction before, but my first thought is just to use pyridine as the solvent.  it will also be the base.