Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: kukurbituril on July 05, 2011, 10:13:19 AM
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Hello, here is the question: can DMF act as a hydride donor? If it is so, could you post some reference??
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I think that NO :-\
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Can't say I've ever heard of DMF acting as a hydride donor, but formic acid can. What type of functional group are you trying to reduce?
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I´ve got a imide group in my molecule and in mass spectra I see the mass of 2 more then my desired product. So one hypothesis was that DMF can somehow act as a reducting agent (reaction is catalysed by palladium) and one carbonyl is reduced to hydroxyl.
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Have you run an IR or NMR on the substrate to confirm the reduction?
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If you obtained your mass spectrum via LCMS, the method of ionization is often through protonation. Typically the eluent is a percentage of formic acid in water and DMF. This maybe where you get your hyride.