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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: asa029 on September 07, 2011, 08:27:38 AM

Title: Pd-catalyzed coupling: possible catalyst posions.
Post by: asa029 on September 07, 2011, 08:27:38 AM

Are there any well-known posions/deactivators for Pd-catalyzed coupling reactions? I think I read once that MeOH might deactivate such reactions, but I'm not able to find any articles on the subject. Does anyone have any input?

Title: Re: Pd-catalyzed coupling: possible catalyst posions.
Post by: OC pro on September 08, 2011, 11:54:46 AM

MeOH is complete nonsense. As Pd poisons/deactivators are actually known:
Sulfur-containing substances (there is a hydrogantion using diphenylsulfide as poison), amines and of course air (leading to Pd(II)-species).

Title: Re: Pd-catalyzed coupling: possible catalyst posions.
Post by: fledarmus on September 08, 2011, 12:12:34 PM

Lead salts and quinoline are fairly widely used