Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: AlphaScent on October 18, 2012, 11:26:44 AM
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A hydrolysis of an acetate done in with 10% NaOH in Methanol. The work up says to wash with 1 N HCl. I say to extract my product with hexanes and then wash. What do you think?
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Wash it with acid first then extract, methanol/water and hexane don't mix.
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A hydrolysis of an acetate done in with 10% NaOH in Methanol. The work up says to wash with 1 N HCl. I say to extract my product with hexanes and then wash. What do you think?
Why do you think the work-up is described as given? How will things be affected with your work-up?
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I have done this reaction on similar compound except this has one double bond, where the other was a diene. What I did before was extract then wash, 99% yield. I thought it odd the procedure given to me from a grad thesis was opposite. I am going to wash first with 1 N HCl. Ill post results in a few hours... Wash with 1 N HCl until acidic, extract with hexanes..wash with brine, filter and remove solvent i.v....should be great...
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A hydrolysis of an acetate done in with 10% NaOH in Methanol. The work up says to wash with 1 N HCl. I say to extract my product with hexanes and then wash. What do you think?
I thing you need to add HCl first because Na-salt is not soluble in hexane...