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Chemistry Forums for Students => Analytical Chemistry Forum => Topic started by: GSR on December 28, 2005, 08:33:35 AM

Title: derivatization for GC-MS
Post by: GSR on December 28, 2005, 08:33:35 AM

Hi,

can anybody  give detailed information on derivatizing a natural product sample with diazomethane, and purification procedures for side products etc... which I need for the GC-MS analysis.

thanks in advance

GSR

Title: Re:derivatization for GC-MS
Post by: jwesterway on January 18, 2006, 08:09:09 AM

This is highly dependant on the sample, diaztisation is used as a derivitising agent for many functional groups to increase their volitility and/or stability under GC analysis. What is the sample comprised of?

-josh

Title: Re:derivatization for GC-MS
Post by: Mitch on January 18, 2006, 12:26:34 PM

Whats the Molecular Weight? Why can't you use GC-MS?