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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: rose55 on November 08, 2012, 07:51:52 AM

Title: Why do we acidify silica gel?
Post by: rose55 on November 08, 2012, 07:51:52 AM

Hi all,
I am using silica gel for sludge sample cleanup. Ive found some people acidify the silica (10-30%) so I activate silica at 350 Oc first and then acidify 10%, but I dont know the acid role. seems some kind of oxidation of impurities by acid. Is that true? Does anyone here have the experience of sludge sample cleanup?

Thank you in advance for your *delete me*
Rose

Title: Re: Why do we acidify silica gel?
Post by: Doc Oc on November 08, 2012, 09:17:29 AM

It depends on what you're purifying.  Some people will add acid the help elute carboxylic acids and base to help elute free amines.

Title: Re: Why do we acidify silica gel?
Post by: rose55 on November 08, 2012, 07:35:34 PM

Quote from: Doc Oc on November 08, 2012, 09:17:29 AM

It depends on what you're purifying.  Some people will add acid the help elute carboxylic acids and base to help elute free amines.

Thank you for your reply.
I am going to cleanup the sample for eluting of triclosan, 2,7-DCDD and 2,4-dichlorophenol. but seems it is more a help for getting rid of matrix interference!
any idea?