Chemical Forums

Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: constant thinker on January 06, 2006, 09:25:04 PM

Title: Indigenous compounds causing Dissociative effects.
Post by: constant thinker on January 06, 2006, 09:25:04 PM

Does anybody know of any compounds that are indingenous in the body that cause a dissociative type effect? Or which neurotransmitters are primarily involved in this feeling?

By this I don't mean the biological function and obviously not the chemical funtion. I mean the feeling that your disconnected.

Also if you know it can you tell me what area of the brain the majority of the receptors are for these neurotransmitters or the chemical.

Does anyone know of any good books on the workings of the human brain that iseasy to understand but not like an easy overall book?

Title: Re:Indigenous compounds causing Dissociative effects.
Post by: limpet chicken on January 06, 2006, 11:28:26 PM

It is primarily drugs which act as an antagonist at glutamate modulated NMDA receptors that act as dissociatives, good examples would be phencyclidine, rollicyclidine, eticyclidine etc., ketamine, dextromethorphan (never had any effects with DXM myself) and MK-801.

In my experience, strong kappa opioid agonists can have very dissociative feelings/effects also, but its mainly NMDA ligands that have definitive effects as dissociatives.

Title: Re:Indigenous compounds causing Dissociative effects.
Post by: constant thinker on January 07, 2006, 04:43:56 PM

Thank you Limpet Chicken.