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Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: wyuen258 on December 10, 2012, 06:39:40 AM

Title: Biochemical molecule structure please help
Post by: wyuen258 on December 10, 2012, 06:39:40 AM
(http://img845.imageshack.us/img845/4438/43085248262835822073515.jpg)
what is the name of this Molecule?? Thanks in advance!
Title: Re: Biochemical molecule structure please help
Post by: Borek on December 10, 2012, 06:56:59 AM
Try google image search.
Title: Re: Biochemical molecule structure please help
Post by: wyuen258 on December 10, 2012, 07:13:39 AM
I have tried already. Nothing close came up  :(
Title: Re: Biochemical molecule structure please help
Post by: fledarmus on December 10, 2012, 07:20:43 AM
Do you have access to Scifinder? Try putting in the entire molecule, and if that doesn't give you an answer, put in pieces of it and do substructure searches.
Title: Re: Biochemical molecule structure please help
Post by: Borek on December 10, 2012, 07:25:49 AM
Strange. I did an image search with Google Chrome (using the url of the image, but I don't see why searching with the image itself shouldn't work) and got one hit, which was exactly what you are looking for. Took me just a few seconds. Note I am not talking about standard search, but about image search. Same Google, different tool.

If you were in the mainland China I would suspect China firewall to block the result, but you are not.
Title: Re: Biochemical molecule structure please help
Post by: sjb on December 10, 2012, 07:29:11 AM
Deep breath  (E,2S,3R,5R,8R,9S)-10-[(2R,3R,4R,5S,6R)-6-[(1S,2R,3S,4S,5R,11S)-12-[(1R,3S,5S,7R)-5-[(8S)-9-[(2R,3R,4R,5R,6S)-6-[(E,2S,3S,6S,9R,10R)-10-[(2S,4R,5S,6R)-6-[(2R,3R)-4-[(2R,3S,4R,5R,6S)-6-[(2S,3Z,5E,8R,9S,10R,12Z,17S,18R,19R,20R)-21-[(2R,3R,4R,5S,6R)-6-[(Z,3R,4R)-5-[(1S,3R,5R,7R)-7-[2-[(2R,3R,5S)-5-(aminomethyl)-3-hydroxy-tetrahydrofuran-2-yl]ethyl]-2,6-dioxabicyclo[3.2.1]octan-3-yl]-3,4-dihydroxy-pent-1-enyl]-3,4,5-trihydroxy-tetrahydropyran-2-yl]-2,8,9,10,17,18,19-heptahydroxy-20-methyl-14-methylene-henicosa-3,5,12-trienyl]-3,4,5-trihydroxy-tetrahydropyran-2-yl]-2,3-dihydroxy-butyl]-4,5-dihydroxy-tetrahydropyran-2-yl]-2,6,9,10-tetrahydroxy-3-methyl-dec-4-enyl]-3,4,5,6-tetrahydroxy-tetrahydropyran-2-yl]-8-hydroxy-nonyl]-1,3-dimethyl-6,8-dioxabicyclo[3.2.1]octan-7-yl]-1,2,3,4,5-pentahydroxy-11-methyl-dodecyl]-3,4,5-trihydroxy-tetrahydropyran-2-yl]-2,5,8,9-tetrahydroxy-N-[(E)-3-(3-hydroxypropylamino)-3-oxo-prop-1-enyl]-3,7-dimethyl-dec-6-enamide (http://en.wikipedia.org/w/index.php?title=Palytoxin&oldid=527326328). Or something like that :)
Title: Re: Biochemical molecule structure please help
Post by: fledarmus on December 10, 2012, 07:31:19 AM
Which is why we do occasionally still use common names  :D
Title: Re: Biochemical molecule structure please help
Post by: AWK on December 10, 2012, 07:56:31 AM
This is a picture from wikipedia!
Title: Re: Biochemical molecule structure please help
Post by: wyuen258 on December 10, 2012, 08:53:07 AM
I tried again but still got no match may be I misused google search. Thanks for everyone's *delete me* :)
Title: Re: Biochemical molecule structure please help
Post by: AWK on December 11, 2012, 01:02:13 AM
search: Palytoxin
Title: Re: Biochemical molecule structure please help
Post by: curiouscat on December 11, 2012, 01:52:12 PM
That's a fascinating molecule.

How does the coral itself synthesize such a complex molecule, anyone know?

Also, do coral cells not have Na-K pumps? How does Palytoxin not poison the coral?
Title: Re: Biochemical molecule structure please help
Post by: Arkcon on December 11, 2012, 03:57:08 PM
The simplest answer is that it contains the toxin in an inactive form, or keeps it in a cellular vesicle to protect itself.  Or maybe its particular cell membrane ion pumps are simply immune.  Although, generally speaking, all cells have ion pumps to alter their interior environment and local environment, this charge differential is easily noticed, and manipulated with micro-electrodes.  This is the basis of the earliest work with neurons.  I wanted to provide a link, but Wikipedia is a little all over the place on the topic.
Title: Re: Biochemical molecule structure please help
Post by: curiouscat on December 11, 2012, 11:31:01 PM
Are vesicles typically impermeable to such molecules?
Title: Re: Biochemical molecule structure please help
Post by: Messi on December 12, 2012, 12:35:20 AM
How would someone confirm they made that above structure?

Wouldn't the NMR be too complicated?
Title: Re: Biochemical molecule structure please help
Post by: AWK on December 12, 2012, 01:15:14 AM
J. Am. Chem. Soc., 1981, 103 (9), pp 2491–2494 
Title: Re: Biochemical molecule structure please help
Post by: Deauxboy2 on December 14, 2012, 10:08:06 PM
That's a fascinating molecule.

How does the coral itself synthesize such a complex molecule, anyone know?

Also, do coral cells not have Na-K pumps? How does Palytoxin not poison the coral?

The coral is probably not responsible for biosynthesis of the compound.  My guess is that it is made by a cynaobacterial symbiont of the coral.