Chemical Forums

Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: GSR on January 24, 2006, 10:35:19 AM

Title: how to increaseThiol yields
Post by: GSR on January 24, 2006, 10:35:19 AM

Hi,

does anyone know the procedure/literature reference to increase the yields of thiols which are obtained by reacting benzyl chloride derivatives and thiourea.

thanks in advace

GSR

Title: Re:how to increaseThiol yields
Post by: movies on January 29, 2006, 02:37:44 PM

I don't have a reference, but one common way is to add sodium iodide or tetrabutylammonium iodide.  Those salts form some benzyl iodide in solution, which is a lot more reactive that the chloride version.

Title: Re:how to increaseThiol yields
Post by: GSR on January 30, 2006, 08:44:47 PM

thanks a lot I will try this method.

GSR