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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: 408 on September 17, 2013, 09:03:47 PM

Title: C-N heterocyclic dephenylation.
Post by: 408 on September 17, 2013, 09:03:47 PM

I have a rather electron poor heterocycle that I am building up. The easy synthetic route will leave it phenyl-substitued. The difficult route, benzyl substituted.  Obviously benzyl is easy to remove.  But what about phenyl?  I have seen a couple hardcore dephenylations using stuff like sodium in liquid ammonia, but is there anything easier?

thanks,
408.

Title: Re: C-N heterocyclic dephenylation.
Post by: 408 on September 19, 2013, 12:14:15 AM

p-methoxysubstituted phenyl can be removed with CAN :)