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Specialty Chemistry Forums => Other Sciences Question Forum => Topic started by: cristiro on March 17, 2006, 06:44:12 AM

Title: 1-methylcyclopropyl methyl ketone
Post by: cristiro on March 17, 2006, 06:44:12 AM

How pracically is obtained, I did some search and nothig about this. Thank you.

Title: Re:1-methylcyclopropyl methyl ketone
Post by: Albert on March 19, 2006, 03:20:16 PM

The following reaction should have a good yield.


EDIT: picture removed.

Title: Re:1-methylcyclopropyl methyl ketone
Post by: Mitch on March 19, 2006, 03:41:05 PM

Albert:

1. Is this a carbene reaction?
2. If so, aren't you missing a carbon in the product?

Title: Re:1-methylcyclopropyl methyl ketone
Post by: Albert on March 19, 2006, 03:54:01 PM

Oh, yes. Sorry, I'm not very used to working with ChemDraw.

Title: Re:1-methylcyclopropyl methyl ketone
Post by: movies on March 20, 2006, 04:40:14 PM

Looks good to me.

You could possibly do it the other way around as well, using a diazocompound derived from ethyl methyl ketone and ethylene.

Another option would be to use a Simmons-Smith reagent which uses CH₂I₂ and [Zn-Cu] to achieve the cyclopropanation.  I'm not 100% positive that it works with enones, however.

Title: Re: 1-methylcyclopropyl methyl ketone
Post by: cristiro on July 15, 2006, 07:55:27 AM

Looks good to me,too. Thank you.