Chemical Forums
General Forums => Generic Discussion => Topic started by: kriggy on January 08, 2015, 12:22:36 PM
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http://cen.acs.org/articles/93/web/2015/01/Novel-Bacteria-Fighter-Unearthed.html
(link to paper) http://tinyurl.com/pnalrj9
This is interesting, especialy the method they cultivated the bacteria in soil.
Few questions:
a) how long could it take for this stuff to reach market? 10 years? Or could it be sooner since it is 1st new antibiotic discovered since last 20(?) years?
b) that NMRs, are those interpreted by person or any software to help with that? I know its lot about experience but i just cant see a way how can anyone build a structure from those peaks
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I doubt this will ever reach the market. It is too complex for large scale production as well as being a peptide. I would guess a med. chem program would find simpler structures.
As for structure determination. NMR will give you the complete structure, especially if you use 13C feedstocks in the culture medium. There are plenty of examples in the recent literature. see http://quintus.mickel.ch/2014/09/07/fungal-metabolites (http://quintus.mickel.ch/2014/09/07/fungal-metabolites) for an example and references.
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Could it be produced by biochemical ways? Geneticaly modified bacteria to overproduce this stuff? I mean vancomycin (http://en.wikipedia.org/wiki/Vancomycin) looks even more complex and is used.
I know that NMR gives the whole structure, i was just wondering how much time was spent interpretting those spectra.
Thanks for link, will read for sure :)
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I dare say it could be produced by some form of genetic engineering. The problem there is obtaining the quantities and maintaining the supply. As far as I know you need quite a high titre of the compound produced in the modified E.coli or whatever other medium they use these days. So it's not as simple as one may like to think.
Then it needs to be formulated and it's ADME studied in detail. All this takes lots of time and lots of money.