Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: prachiti on March 10, 2017, 11:39:48 PM
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I am to purify 4-isopropyl amine of its coloured impurities. Vacuum distillation is not feasible because we do not have a strong vacuum pump (M.P.- 183 degree centigrade). Should i try activated charcoal? If not, then what other methods can i apply?
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On what sort of scale? Chromatography? Recrystallisation as a salt?
What is the actual compound (the name seems missing something)
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A chromatographic scale is what i was looking for since i have less amount of compound available.
The compound goes by 4-isopropyl aniline (attaching an image). Regarding the impurities, they are coloured and four in number apart from the amine (with a TLC reference), I tried out purification by activated charcoal. It however, didn't turn out as i expected.
Purification by salt formation didn't work as expected and showed same TLC results before treating the sample.
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Do you have any idea what your contaminants might be? Try e.g. TLC in various EtOAc/hexanes mixtures to see if you get separation that way.
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Do you have any idea what your contaminants might be? Try e.g. TLC in various EtOAc/hexanes mixtures to see if you get separation that way.
DCM / MeOH tends to be better for amines in my experience. Column chromatography of this should be fairly straightforward.
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I am onto a CHCl3 column and it is running well. I am getting my amine in pure form.
A TLC shows in total 4 components. I am assuming one of the contaminants is an N-oxide. The others i am clueless about.
Thank you!
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Could you give some more detail on the exact reaction you're doing?
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Do the hydrocloride ( by treatment with HCL:Et2O) and then NaOH washing.