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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: zuriel on January 13, 2018, 08:20:24 PM

Title: Any useful tips for cooling to -10 degC
Post by: zuriel on January 13, 2018, 08:20:24 PM

Hi,

I want to try a particular reaction at -10 degC and I'm looking for suggestions on how to go about this. I've had a salt-ice bath suggested (1:1 ratio salt:ice by weight) but I'm wondering are there any other methods that any of you might know of?

Cheers!

Title: Re: Any useful tips for cooling to -10 degC
Post by: zarhym on January 15, 2018, 11:32:27 PM

Ice/Calcium chloride 1:1

Liquid N2/Ethylene glycol

Ice/Acetone 1 :1

Title: Re: Any useful tips for cooling to -10 degC
Post by: phth on January 16, 2018, 02:06:36 AM

Quote from: zuriel on January 13, 2018, 08:20:24 PM

Hi,

I want to try a particular reaction at -10 degC and I'm looking for suggestions on how to go about this. I've had a salt-ice bath suggested (1:1 ratio salt:ice by weight) but I'm wondering are there any other methods that any of you might know of?

Cheers!

 these lists are pretty useful as a reference
https://en.wikipedia.org/wiki/List_of_cooling_baths
https://en.wikipedia.org/wiki/Cooling_bath

One could also try to find a walk in freezer or adjustable fridge. 

Title: Re: Any useful tips for cooling to -10 degC
Post by: Doc Oc on January 16, 2018, 02:18:54 PM

The easiest is to pour sodium chloride over wet ice and stir well.

Title: Re: Any useful tips for cooling to -10 degC
Post by: zuriel on January 21, 2018, 08:16:34 AM

Thanks everyone, I tried the liquid nitrogen/glycol and salt/ice suggestions and they both worked quite well!

Title: Re: Any useful tips for cooling to -10 degC
Post by: P on January 23, 2018, 08:40:18 AM

Liquid N2 sounds a bit cold for -10C.  I was going to suggest dry ice in IPA. Even that might be too cold.