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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: frostbite on April 20, 2018, 04:59:50 PM

Title: Chromaphore addition to M-PEgs
Post by: frostbite on April 20, 2018, 04:59:50 PM

I am looking for a suitable chromophore to add to m-peg-OH and m-peg-amine. I'm hoping there is a single chromophore that can be attached to both end groups in a one pot method. However, if not, are there two chromophores that can be conjugated in a stepwise fashion to allow differentiation of m-PEG-OH form m-PEG-amine species using a UV detector on an HPLC. I am hoping ot be able to determine mole% content.

If UV HPLC is not a suitable instrument for determining m-peg-oh and m-peg-amine content, is there another practical instrumental method I could use?

Thank you for any *delete me*!!

TA

Title: Re: Chromaphore addition to M-PEgs
Post by: wildfyr on April 21, 2018, 10:29:20 PM

A dye with an activated Ester on it perhaps