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Chemistry Forums for Students => Undergraduate General Chemistry Forum => Topic started by: robert_johnston on May 17, 2018, 08:04:48 AM

Title: Medicinal Chemistry
Post by: robert_johnston on May 17, 2018, 08:04:48 AM

Hi, I need help answering a few Multiple Choice Questions,

1. What technique is not used for structural analyses of possible lead compounds?
(a) NMR
(b) IR
(c) X-Ray crystallography
(d) MS
(e) MRI

For this question, I think MRI is correct because the main use of an MRI is as a technique for medical imaging, specifically in radiology.

2. . Why are one pot-one structure libraries nowadays preferably used in drug development instead of
combinatorial libraries in which the structures are mixed?
(a) They contain more structures
(b) They are cheaper to make
(c) They do not require chemical synthesis
(d) They are more easy to patent
(e) They allow more and simpler screening methods

For this question, I think that (e) is correct because one-pot structures are individual libraries and it seems to make sense that it would be simpler to screen.

Title: Re: Medicinal Chemistry
Post by: wildfyr on May 17, 2018, 08:44:02 AM

I agree with your answers  :)

Title: Re: Medicinal Chemistry
Post by: Borek on May 17, 2018, 08:57:40 AM

Quote from: robert_johnston on May 17, 2018, 08:04:48 AM

structural analyses of possible lead compounds?

Quote

I think MRI is correct because the main use of an MRI is as a technique for medical imaging, specifically in radiology.

Perhaps I am missing something, but I don't see how structural analysis of lead compounds is part of medical imaging.

Title: Re: Medicinal Chemistry
Post by: Babcock_Hall on May 17, 2018, 09:09:08 AM

I missed the word "not" the first time around.

Title: Re: Medicinal Chemistry
Post by: robert_johnston on May 17, 2018, 10:57:37 AM

Perhaps I am missing something, but I don't see how structural analysis of lead compounds is part of medical imaging.
[/quote]

The question says which one is NOT used for structural analysis.

Title: Re: Medicinal Chemistry
Post by: Borek on May 17, 2018, 01:29:07 PM

Quote from: robert_johnston on May 17, 2018, 10:57:37 AM

The question says which one is NOT used for structural analysis.

Missed that :(

Title: Re: Medicinal Chemistry
Post by: robert_johnston on May 17, 2018, 04:49:02 PM

I found another question that I am completely lost on:

What is a false statement regarding enzyme inhibitors and their Ki and IC50 value?
(a) The lower the Ki value the better the inhibition
(b) The lower the IC50 value the better the inhibition
(c) If the Ki value is low it follows that the IC50 is also low
(d) If the IC50 value is low it follows that the Ki value is also low
(e) For enzyme inhibitors the EC50 and IC50 values are identical

To be honest, I have no idea but if I was to guess, I would say (e) because IC50 is inhibition and EC50 is not.

Title: Re: Medicinal Chemistry
Post by: Babcock_Hall on May 17, 2018, 09:37:03 PM

You might look at the paper by Cheng and Prusoff (1973?) for some discussion of the relationships between K_i and IC50 values.