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Topic: LAH problems (Read 3826 times)
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bisser
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LAH problems
«
on:
April 16, 2006, 09:14:01 PM »
Can LAH do the same? ( replacing -CL with -H)
i don't quite understand the mechanism.
and are there any alternative ways in doing so?
thanks
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Organic Minion
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Re: LAH problems
«
Reply #1 on:
April 16, 2006, 09:19:22 PM »
Yes, LAH can displace good leaving groups to make alkanes. It is probably most common with mesylates or tosylates.
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formamide
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Re: LAH problems
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Reply #2 on:
May 29, 2006, 11:41:55 PM »
I would prepare the chloride intermediate, J, using PCl3, then react with Mg to get the Grignard reagent in THF, then quench with D2O. Advantage- D2O is much cheaper than LAD.
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LAH problems