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Topic: LAH problems  (Read 3826 times)

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bisser

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LAH problems
« on: April 16, 2006, 09:14:01 PM »
Can LAH do the same? ( replacing -CL with -H)

 i don't quite  understand the mechanism.

and are there any alternative ways in doing so?

thanks



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Re: LAH problems
« Reply #1 on: April 16, 2006, 09:19:22 PM »
Yes, LAH can displace good leaving groups to make alkanes.  It is probably most common with mesylates or tosylates.

formamide

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Re: LAH problems
« Reply #2 on: May 29, 2006, 11:41:55 PM »
I would prepare the chloride intermediate, J, using PCl3, then react with Mg to get the Grignard reagent in THF, then quench with D2O. Advantage- D2O is much cheaper than LAD. 

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