June 04, 2024, 08:46:15 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: amide hydrolysis  (Read 2469 times)

0 Members and 1 Guest are viewing this topic.

Offline helper

  • Regular Member
  • ***
  • Posts: 69
  • Mole Snacks: +3/-1
amide hydrolysis
« on: January 07, 2014, 05:17:15 PM »
can we do this  basic hydrolysis in order to get sulfonylamide?
may we say that the product wouldn't be a salt, because if we are in  basic solution  and we have a hydrogen that is acidic, it would left?
Logged

Offline Babcock_Hall

  • Chemist
  • Sr. Member
  • *
  • Posts: 5633
  • Mole Snacks: +324/-24
Re: amide hydrolysis
« Reply #1 on: January 07, 2014, 05:29:59 PM »
Do you think that the sulfonamide would also hydrolyze?  Why or why not?
Logged

Offline TheUnassuming

  • Chemist
  • Full Member
  • *
  • Posts: 461
  • Mole Snacks: +48/-1
Re: amide hydrolysis
« Reply #2 on: January 08, 2014, 09:22:52 AM »
Hydroxide would cleave the amide bond you have. 
To answer your second question, check out the pKa in this often handy Evans' lab pka table (http://evans.harvard.edu/pdf/evans_pka_table.pdf). 
Logged
When in doubt, avoid the Stille coupling.
Pages: [1]   Go Up
« previous next »
Sponsored Links