Hi y'all--thiazolidinediones are used as carboxylic acid mimetics in drug design (TZD's for example). I understand the N provides electron delocalization to the O’s which increases their H-acceptor strength. Not sure how the S contributes to this although that is not my actual question. I am trying to understand if a dioxy-triazine would also function as a carboxylic acid mimetic? Not sure if my numbering is correct, but I would call this (4,6-dioxy)1,2,5-triazine. Apologies if this is not clear but I am a biologist, not a chemist! Thanks for your thoughts.