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Why Nucleophilic substitution of pyridine undergoes at C2 and C4 but not on C3?
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AussieKenDoll:
Why Nucleophilic substitution of pyridine undergoes predominantly at C2 and C4 but not on C3, why?
spirochete:
Draw the mechanism, including all resonance structures for the anionic intermediate. Then, think about them. Where is negative charge more stable in anions? That will explain it.
AussieKenDoll:
the positive charge is on C2, C4 and C6 on the resonance structures? but I still do not understand why
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