December 10, 2022, 04:33:53 AM
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Topic: Acid Protection Cross coupling reactions  (Read 595 times)

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Offline Cocainut

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Acid Protection Cross coupling reactions
« on: August 16, 2019, 11:29:42 AM »
Whenever I search in litterature for a coupling reaction I often find that the carboxylic acid is being protected and I am curious if there are any particular reasoning behind this?
I've tried searching the litterature but I am having trouble finding any useful answers.

Offline OrganicDan96

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Re: Acid Protection Cross coupling reactions
« Reply #1 on: August 16, 2019, 12:00:51 PM »
migth be that carboxylic acids are very hard to handle. they stick to silica so not easy to column and can be a bit water soluble making isolation hard. what is the reaction you are investigating?

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