September 23, 2019, 03:24:09 AM
Forum Rules: Read This Before Posting


Topic: Acid Protection Cross coupling reactions  (Read 109 times)

0 Members and 1 Guest are viewing this topic.

Offline Cocainut

  • Very New Member
  • *
  • Posts: 1
  • Mole Snacks: +0/-0
Acid Protection Cross coupling reactions
« on: August 16, 2019, 11:29:42 AM »
Whenever I search in litterature for a coupling reaction I often find that the carboxylic acid is being protected and I am curious if there are any particular reasoning behind this?
I've tried searching the litterature but I am having trouble finding any useful answers.

Offline OrganicDan96

  • Full Member
  • ****
  • Posts: 203
  • Mole Snacks: +17/-1
Re: Acid Protection Cross coupling reactions
« Reply #1 on: August 16, 2019, 12:00:51 PM »
migth be that carboxylic acids are very hard to handle. they stick to silica so not easy to column and can be a bit water soluble making isolation hard. what is the reaction you are investigating?

Sponsored Links