As always, thank you for your quality answers
I have a relatively ambarassing problem. I need to do an aldol condensation on an aromatic compound. My compound have aldehyde and ester fonctionnal groups and when i do the synthesis, i got almost no product. I have it on TLC and i mostly recover my starting material, even if i have 2 new spots for the reaction products.
I dissolve my thiamine (catalyst) on water/Methanol (1:2) and add NaOH at 0degree. I used to believe that i added NaOH to thiamine too fast, but i have done it slowly,drop by drop, with some time between each of them. There is no improvements.
does anybody have a suggestion on what am i doing wrong here?