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Substitutions involving the trifluoromethanesulfonyl group leaving have helped me twice at different points in my career.
I used trimethylsilyl trifluoromethanesulfonate and tetrabutylammonium iodide in place of TMSI. I was trying to remove the methyl ester groups from a very labile phosphate ester. TMSI is not the easiest compound with which to work.
The thiol-ene reaction. I have used it successfully for the last 3 companies I've worked at, and if the desired properties are met of my latest batch of compounds, my current company as well.
synthesis of amides using pentafluorophenyl esters are a reaction i do all the time
Quote from: OrganicDan96 on April 20, 2020, 05:24:55 PMsynthesis of amides using pentafluorophenyl esters are a reaction i do all the timeThis chemistry relies mainly on the easy leaving of pentafluorophenoxide group, is this true? Did I miss anything here?
Right now, Suzuki, Ullmann, and Buchwald couplings. I do these every day.I'll say one thing. I do not like Ullmann couplings. Dirty, harsh, annoying to work with. Some reactions go fine, others need a constant feeding with catalyst and ligand.
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