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Topic: Decarboxylation of a solution of Orotic acid?  (Read 973 times)

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Offline Jeffrey777

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Decarboxylation of a solution of Orotic acid?
« on: October 17, 2019, 12:10:53 PM »
What would be the best method for decarboxylation of orotic acid?   Can sodium hydroxide be used for this purpose?
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Offline hollytara

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Re: Decarboxylation of a solution of Orotic acid?
« Reply #1 on: October 17, 2019, 12:22:19 PM »
Do you have access to the enzyme? 

See  Biochemistry. 2009 Sep 15; 48(36): 8738–8745.
doi: 10.1021/bi901085m
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Offline Jeffrey777

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Re: Decarboxylation of a solution of Orotic acid?
« Reply #2 on: October 17, 2019, 01:54:11 PM »
I know there is an enzyme decarboxylase, but this is meant to be an experiment in prebiotic chemistry, showing the formation of uracil when there were no enzymes.
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Offline Jeffrey777

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Re: Decarboxylation of a solution of Orotic acid?
« Reply #3 on: October 17, 2019, 01:55:39 PM »
Thanks for the quick reply, btw!
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Offline AWK

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Re: Decarboxylation of a solution of Orotic acid?
« Reply #4 on: October 17, 2019, 03:58:33 PM »
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AWK

Offline Jeffrey777

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Re: Decarboxylation of a solution of Orotic acid?
« Reply #5 on: October 17, 2019, 04:08:35 PM »
Thank you very much for that!  Actually I did come across that article, and so that was always a possible option.  I just wanted to see if anybody here had any other ideas.  Thanks very much!
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